Influence of acetylcholine, isoproterenol, quinidine and ouabain on effective refractory periods of atrial and ventricular myocardium in the dog.
Arch Int Pharmacodyn Ther
; 227(2): 206-19, 1977 Jun.
Article
en En
| MEDLINE
| ID: mdl-907407
ABSTRACT
Acetylcholine-, isoproterenol-, quinidine- and ouabain-induced variations of the effective refractory periods (E.R.P.) of the non-specialized atrial and ventricular tissue have been explored in the dog by the extra-stimulus method during total cardiopulmonary by-pass. Acetylcholine significantly shortens the E.R.P. of atrial fibers, but does not provoke any change in the ventricular tissue, whereas a parallel decrease of atrial and ventricular E.R.P. is noted with isoproterenol. Quinidine induces a larger increase of the E.R.P. in the atrium than in the ventricle. The ouabain-induced shortening of the E.R.P. in the atrium is more marked than in the ventricle but is followed by a secondary increase which depends on both time after injection and dose. Hypotheses about the mechanisms of these effects, their importance in fibrillation and their relation to clinical uses are discussed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ouabaína
/
Quinidina
/
Periodo Refractario Electrofisiológico
/
Acetilcolina
/
Isoproterenol
/
Contracción Miocárdica
/
Conducción Nerviosa
Límite:
Animals
Idioma:
En
Revista:
Arch Int Pharmacodyn Ther
Año:
1977
Tipo del documento:
Article