Neuronal heterotopias in the developing cerebral cortex produced by neurotrophin-4.
Neuron
; 18(3): 505-17, 1997 Mar.
Article
en En
| MEDLINE
| ID: mdl-9115743
ABSTRACT
The marginal zone (MZ) of embryonic neocortex is crucial to its normal development. We report that neurotrophin-4 (but not NT3 or NGF), applied to embryonic rodent cortex in vitro or in vivo, produces heterotopic accumulations of neurons in the MZ. Although heterotopia production is TrkB mediated, BDNF is >10-fold less effective than NT4. Heterotopic neurons have the same birth date and phenotype as normal MZ neurons; they are not the result of NT4-induced proliferation or rescue from apoptosis. We suggest that NT4 causes excess neurons to migrate into the MZ and thus may play a role in normal MZ formation as well as in the pathogenesis of certain human cortical dysplasias.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Anomalías Inducidas por Medicamentos
/
Corteza Cerebral
/
Coristoma
/
Factores de Crecimiento Nervioso
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neuron
Asunto de la revista:
NEUROLOGIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos