Efficacy and tolerance of mesalazine suppositories vs. hydrocortisone foam in proctitis.
Aliment Pharmacol Ther
; 11(2): 335-40, 1997 Apr.
Article
en En
| MEDLINE
| ID: mdl-9146772
ABSTRACT
BACKGROUND:
Topical treatments with steroids or mesalazine are the most effective treatments for idiopathic proctitis.AIM:
To compare the efficacy and tolerance of mesalazine suppositories vs. hydrocortisone acetate foam in the treatment of acute proctitis. PATIENTS ANDMETHODS:
242 patients with active idiopathic proctitis were randomized to receive once daily either one Pentasa suppository (mesalazine 1 g) or 100 mg hydrocortisone (Colofoam) for 14-21 days (until remission). Disease activity and tolerance of the treatments were assessed using a daily questionnaire, by physician assessment, and endoscopy score.RESULTS:
Both treatments induced a significant reduction in disease activity. Mesalazine suppositories were significantly more effective than hydrocortisone on rectal blood loss (P = 0.002) and mucus (P = 0.02) parameters, and on the degree of the decrease in endoscopy score (P = 0.02). No significant difference was observed between treatments concerning histology or tolerance.CONCLUSION:
Mesalazine suppositories were as well-tolerated as hydrocortisone foam, but were more effective for some parameters of disease activity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proctitis
/
Antiinflamatorios no Esteroideos
/
Ácidos Aminosalicílicos
/
Antiinflamatorios
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Aliment Pharmacol Ther
Asunto de la revista:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
1997
Tipo del documento:
Article
País de afiliación:
Francia