Surface plasmon resonance analysis of topoisomerase I-DNA binding: effect of Mg2+ and DNA sequence.
Anticancer Drugs
; 8(4): 336-44, 1997 Apr.
Article
en En
| MEDLINE
| ID: mdl-9180386
Surface plasmon resonance detection was used to characterize interactions of human topoisomerase I and DNA. The disassociation of topoisomerase I and DNA is characterized by two rate constants. This suggests two parallel but independent pathways of release. DNA association appears to be complex. Mg2+ was found to increase both disassociation rate constants and may have a detectable effect on topoisomerase I-DNA association. DNA base content did not affect disassociation rate constants or the rate of association.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ADN
/
ADN Bacteriano
/
ADN-Topoisomerasas de Tipo I
/
Magnesio
Límite:
Animals
Idioma:
En
Revista:
Anticancer Drugs
Asunto de la revista:
ANTINEOPLASICOS
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos