Pain affect encoded in human anterior cingulate but not somatosensory cortex.
Science
; 277(5328): 968-71, 1997 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-9252330
ABSTRACT
Recent evidence demonstrating multiple regions of human cerebral cortex activated by pain has prompted speculation about their individual contributions to this complex experience. To differentiate cortical areas involved in pain affect, hypnotic suggestions were used to alter selectively the unpleasantness of noxious stimuli, without changing the perceived intensity. Positron emission tomography revealed significant changes in pain-evoked activity within anterior cingulate cortex, consistent with the encoding of perceived unpleasantness, whereas primary somatosensory cortex activation was unaltered. These findings provide direct experimental evidence in humans linking frontal-lobe limbic activity with pain affect, as originally suggested by early clinical lesion studies.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dolor
/
Corteza Somatosensorial
/
Mapeo Encefálico
/
Afecto
/
Lóbulo Frontal
/
Giro del Cíngulo
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Science
Año:
1997
Tipo del documento:
Article