A repeated-dose dermal toxicity study of hydrophobically modified hydroxypropyl methylcellulose in rats.
J Toxicol Sci
; 22(3): 255-80, 1997 Aug.
Article
en En
| MEDLINE
| ID: mdl-9279827
ABSTRACT
A six-month repeated-dose dermal toxicity study followed by a 30-day recovery test of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC), a new cellulose derivative used as a thickener for topical pharmaceuticals, was conducted using rats. Aqueous paste of HM-HPMC was applied to the skin of rats once daily at dose levels up to 60 mg/kg/day, which was the highest dose that could be administered. Items checked included general signs, urinalysis, hematology, ophthalmology, and histopathology. One rat died during the administration period owing to a malignant tumor in the hemopoietic system, which was not attributed to the test substance. Statistically significant differences were found in some test results, but those were not dose-dependent and were considered to be incidental or spontaneous. It was concluded that the test substance was not toxic upon chronic dermal administration at dose levels up to 60 mg/kg/day.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Metilcelulosa
Límite:
Animals
Idioma:
En
Revista:
J Toxicol Sci
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón