[The role of organ cultures of mouse embryonal lung tissue in studying the transplacental blastomogenic effect of benz(alpha)pyrene]. / Rol' organnykh kul'tur émbrional'noi legochnoi tkani myshei v izuchenii transplatsentarnogo blastomogennogo deistviia benz(alpha)pirena

ABSTRACT

Under study was organ cultivation of embryonal pulmonary tissue in mice A and C57B1 given during the pregnancy period BP (4 and 12 mg), pyrene (12 mg) and a solvent (0.4 ml of sunflower oil). Only BP was found to produce marked hyperplastic changes in the pulmonary epithelium and adenomas in organ cultures of the lungs of line A, whereas in the lung cultures of line C57B1 the same dosage of BP resulted in the development of less pronounced hyperplastic changes in the epithelium. However, in both cases in the cultures the effect of BP was dependent on its dosage.