Cell cycle dependent toxicity of an amphiphilic synthetic peptide.
FEBS Lett
; 418(1-2): 101-5, 1997 Nov 24.
Article
en En
| MEDLINE
| ID: mdl-9414104
ABSTRACT
The cytotoxic properties of an amphiphilic synthetic peptide are presented. Comparative analysis of proliferating, differentiated and confluent H9C2 adherent cells and L1210 cells in suspension shows a correlation between toxicity and cell stage (proliferating cells). Electrophysiological measurements on Xenopus laevis oocytes bathed in the peptide also demonstrated the induction of cationic currents, which is voltage and phosphate dependent. These results allow us to hypothesize that the observed toxicity is related to membrane hyperpolarization of proliferating cells at the G1/S cell cycle phase transition.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oocitos
/
Péptidos
/
Ciclo Celular
/
Supervivencia Celular
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
1997
Tipo del documento:
Article
País de afiliación:
Francia