Neurite promotion from ciliary ganglion neurons by gicerin.
Neurochem Int
; 32(1): 23-9, 1998 Jan.
Article
en En
| MEDLINE
| ID: mdl-9460698
ABSTRACT
Gicerin is a cell adhesion molecule of an immunoglobulin superfamily member and transiently expressed on the surface of neurons such as retinal ganglion cells during synaptogenesis. Gicerin is a receptor for NOF (neurite outgrowth factor) that belongs to the laminin family, and mediates neurite extension induced by NOF. As we have reported, gicerin also exhibits homophilic cell adhesion activity, we compared the patterns of extending neurites induced by homophilic and heterophilic cell adhesion activities of gicerin using ciliary ganglion (CG) neurons. CG neurons expressed gicerin and extended neurites on a feeder layer of gicerin-transfected cells, suggesting a neurite extension by gicerin-gicerin (homophilic) interaction. We found that CG neurons cultured on gicerin-transfected cells extended slightly branched neurites, while those cultured on NOF-coated substratum extended many long branched neurites. It is suggested that neurites induced by homophilic or heterophilic cell adhesion activities of gicerin differ in the length and branching.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Moléculas de Adhesión Celular
/
Neuritas
/
Proteínas Aviares
/
Ganglios Parasimpáticos
/
Proteínas del Tejido Nervioso
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Neurochem Int
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón