The potential of retro-inverso peptides as synthetic vaccines.
Dev Biol Stand
; 92: 139-43, 1998.
Article
en En
| MEDLINE
| ID: mdl-9554267
ABSTRACT
Retro-inverso (RI) peptides, also called all-D-retro peptides, have been shown to mimic the antigenic and immunogenic properties of L-peptides successfully. RI peptides corresponding to the loop 141-159 of the VP1 protein of foot-and-mouth disease virus (FMDV) have been synthesized and used to immunize rabbits and guinea pigs. These peptides induced longer-lasting and higher antibody titres in immunized animals than did the corresponding L-peptides and the antibodies cross-reacted strongly with virus particles and with L-peptides. Antisera raised to RI peptides had in vitro virus neutralization titres equal to or better than those obtained after immunization with classical FMDV antigens and L-peptides. In view of their increased stability, RI peptides may overcome some of the shortcomings of synthetic viral vaccines based on L-peptides.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Vacunas Virales
/
Vacunas Sintéticas
/
Cápside
/
Imitación Molecular
/
Fiebre Aftosa
Límite:
Animals
Idioma:
En
Revista:
Dev Biol Stand
Año:
1998
Tipo del documento:
Article
País de afiliación:
Francia