Variation at the MJD locus in the major psychoses.
Am J Med Genet
; 81(5): 440-2, 1998 Sep 07.
Article
en En
| MEDLINE
| ID: mdl-9754631
ABSTRACT
Expansion of triplet repeats has been seen to underlie several disorders that manifest anticipation. Clinical evidence suggests that anticipation occurs in the major psychoses. We studied the distribution of repeat sizes at the Machado-Joseph disease (MJD) locus in a group of patients with the major psychoses. We did not find any large expansions, though 2 patients had alleles that were two repeats larger than in our controls. The difference in allele sizes was larger in the patient sample as compared to the controls. The effect of such large differences might be of functional significance.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos Psicóticos
/
Genoma Humano
/
Secuencias Repetitivas de Aminoácido
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Med Genet
Año:
1998
Tipo del documento:
Article