Localization of the neurokinin 1 (NK-1) receptor in the human antrum and duodenum.
Neurosci Lett
; 253(1): 49-52, 1998 Aug 28.
Article
en En
| MEDLINE
| ID: mdl-9754802
A newly available antibody to the neurokinin-1 receptor (NK-1r) has made it possible to determine the distribution of the NK-1r receptor in human tissue. In the present study the distribution of the NK-1r and substance P have been determined in the human antrum and duodenum by immunocytochemistry. The NK-1r was present on myenteric and submucosal neurons and nerve fibers of the gastro-enteric nervous system. In addition, the receptor was present on spindle-shaped cells in the circular muscle layer, endothelial cells and a population of mucosal cells. In the submucosal plexus NK-1r immunoreactive neurons were surrounded by substance P containing fibers. These results indicate an extensive cellular expression of the NK-1r in the human antrum and duodenum.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Neuroquinina-1
/
Duodeno
/
Mucosa Gástrica
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Mucosa Intestinal
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Plexo Mientérico
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neurosci Lett
Año:
1998
Tipo del documento:
Article
País de afiliación:
Canadá