Ritodrine-related liver injury. Case reports and review of the literature.

ABSTRACT

beta-sympathicomimetic ritodrine chloridrate is a commonly used tocolytic agent for the treatment of preterm labour. Previous reports have described the occurrence of liver test abnormalities during ritodrine administration but the clinical significance and incidence of this side effect are still unclear. We report on two cases including one with a positive rechallenge of liver injury during oral ritodrine administration and a review of the literature.