Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor.
J Bone Joint Surg Br
; 80(5): 907-8, 1998 Sep.
Article
en En
| MEDLINE
| ID: mdl-9768907
ABSTRACT
In a series of 12 patients with inoperable gastric carcinoma who had treatment with a synthetic matrix metalloproteinase inhibitor (Marimastat) for more than one month, six developed a frozen shoulder or a condition resembling Dupuytren's disease. This suggests that the matrix metalloproteinases, a family of naturally occurring proteinases, may be involved in the pathogenesis of these two conditions. Our observation opens avenues for further research which could lead to local or systemic therapeutic interventions for frozen shoulder and Dupuytren's disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bursitis
/
Metaloendopeptidasas
/
Contractura de Dupuytren
/
Inhibidores Enzimáticos
/
Ácidos Hidroxámicos
Límite:
Humans
/
Male
Idioma:
En
Revista:
J Bone Joint Surg Br
Año:
1998
Tipo del documento:
Article
País de afiliación:
Reino Unido