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The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins.
Mann, C J; Anderson, T A; Read, J; Chester, S A; Harrison, G B; Köchl, S; Ritchie, P J; Bradbury, P; Hussain, F S; Amey, J; Vanloo, B; Rosseneu, M; Infante, R; Hancock, J M; Levitt, D G; Banaszak, L J; Scott, J; Shoulders, C C.
Afiliación
  • Mann CJ; MRC Molecular Medicine Group, Imperial College School of Medicine, London W12 ONN, UK.
J Mol Biol ; 285(1): 391-408, 1999 Jan 08.
Article en En | MEDLINE | ID: mdl-9878414
ABSTRACT
The assembly of atherogenic lipoproteins requires the formation in the endoplasmic reticulum of a complex between apolipoprotein (apo)B, a microsomal triglyceride transfer protein (MTP) and protein disulphide isomerase (PDI). Here we show by molecular modelling and mutagenesis that the globular amino-terminal regions of apoB and MTP are closely related in structure to the ancient egg yolk storage protein, vitellogenin (VTG). In the MTP complex, conserved structural motifs that form the reciprocal homodimerization interfaces in VTG are re-utilized by MTP to form a stable heterodimer with PDI, which anchors MTP at the site of apoB translocation, and to associate with apoB and initiate lipid transfer. The structural and functional evolution of the VTGs provides a unifying scheme for the invertebrate origins of the major vertebrate lipid transport system.
Asunto(s)
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apolipoproteínas B / Conformación Proteica / Proteínas Portadoras / Modelos Moleculares / Vitelogeninas Límite: Animals / Humans Idioma: En Revista: J Mol Biol Año: 1999 Tipo del documento: Article País de afiliación: Reino Unido
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apolipoproteínas B / Conformación Proteica / Proteínas Portadoras / Modelos Moleculares / Vitelogeninas Límite: Animals / Humans Idioma: En Revista: J Mol Biol Año: 1999 Tipo del documento: Article País de afiliación: Reino Unido