Reduction of intraspecific aggression in adult rats by neonatal treatment with a selective serotonin reuptake inhibitor
Braz. j. med. biol. res
; 34(1): 121-4, Jan. 2001. tab
Article
em En
| LILACS
| ID: lil-277065
Biblioteca responsável:
BR1.1
ABSTRACT
Most studies suggest that serotonin exerts an inhibitory control on the aggression process. According to experimental evidence, this amine also influences growth and development of the nervous tissue including serotoninergic neurons. Thus, the possibility exists that increased serotonin availability in young animals facilitates a long-lasting effect on aggressive responses. The present study aimed to investigate the aggressive behavior of adult rats (90-120 days) treated from the 1st to the 19th postnatal day with citalopram (CIT), a selective serotonin reuptake inhibitor (20 mg/kg, sc, every 3 days). Aggressive behavior was induced by placing a pair of rats (matched by weight) in a box (20 x 20 x 20 cm), and submitting them to a 20-min session of electric footshocks (five 1.6-mA - 2-s current pulses, separated by a 4-min intershock interval). When compared to the control group (rats treated for the same period with equivalent volumes of saline solution), the CIT group presented a 41.4 percent reduction in the duration of aggressive response. The results indicate that the repeated administration of CIT early in life reduces the aggressive behavior in adulthood and suggest that the increased brain serotoninergic activity could play a role in this effect
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Citalopram
/
Inibidores Seletivos de Recaptação de Serotonina
/
Agressão
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Brasil