Evaluation of five screening tests licensed in Argentina for detection of hepatitis C virus antibodies
Mem. Inst. Oswaldo Cruz
; 100(3): 303-307, May 2005. tab
Article
em En
| LILACS
| ID: lil-411029
Biblioteca responsável:
BR1.1
ABSTRACT
This study was conducted to compare among the most recent generation of five screening tests licensed in Argentina, in order to evaluate which of the tests has the best sensitivity for detection of antibodies against hepatitis C virus (HCV). The tests analyzed were Detect-HCV (3.0) Biochem ImmunoSystems, Canada; Hepatitis C EIA Wiener Lab., Argentina; Equipar HCV Ab, Italy; Murex HCV 4.0, UK and Serodia-HCV particles agglutination test, Japan. The results obtained showed high discrepancy between the different kits used and show that some of the tests assessed have a low sensitivity for anti-HCV detection in both chronic infections and early seroconversion, and indicate that among the commercially available kits in Argentina, Murex HCV 4.0 (UK) and Serodia-HCV particles agglutination test (Japan) have the best sensitivity for HCV screening. Although the sensitivity of the assays is the first parameter to be considered for blood screening, more studies should be carried out to assess the specificity of such assays.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Kit de Reagentes para Diagnóstico
/
Hepatite C
/
Hepacivirus
/
Anticorpos Anti-Hepatite C
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
/
Screening_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Argentina