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Evidence of an association between the O blood group and allergic rhinitis
Falsarella, Nelson; Ferreira, Ana Iara da Costa; Nakashima, Fabiana; Mattos, Cinara de Cássia Brandão de; Mattos, Luiz Carlos de.
Afiliação
  • Falsarella, Nelson; Faculdade de Medicina de São José do Rio Preto. Molecular Biology Department. Immunogenetics Laboratory. São José do Rio Preto. BR
  • Ferreira, Ana Iara da Costa; Faculdade de Medicina de São José do Rio Preto. Molecular Biology Department. Immunogenetics Laboratory. São José do Rio Preto. BR
  • Nakashima, Fabiana; Faculdade de Medicina de São José do Rio Preto. Molecular Biology Department. Immunogenetics Laboratory. São José do Rio Preto. BR
  • Mattos, Cinara de Cássia Brandão de; Faculdade de Medicina de São José do Rio Preto. Molecular Biology Department. Immunogenetics Laboratory. São José do Rio Preto. BR
  • Mattos, Luiz Carlos de; Faculdade de Medicina de São José do Rio Preto. Molecular Biology Department. Immunogenetics Laboratory. São José do Rio Preto. BR
Rev. bras. hematol. hemoter ; Rev. bras. hematol. hemoter;33(6): 444-448, Dec. 2011. tab
Article em En | LILACS | ID: lil-611381
Biblioteca responsável: BR408.1
ABSTRACT

OBJECTIVE:

The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis.

METHODS:

168 patients with allergic rhinitis and 168 control individuals from the same geographical region and paired by gender and age were enrolled in the study. ABO phenotypes were identified in red blood cells using the hemagglutination technique. The Fisher exact and chi-squared tests were employed to compare proportions. Statistical significance was set for an alpha error of 5 percent (p-value < 0.05).

RESULTS:

The overall differences in the frequencies of the ABO phenotypes of patients and controls were marginal (χ2 7.569; degrees of freedom (DF) 3; p-value = 0.055) however the O blood group was associated with allergic rhinitis (χ2 5.764; DF 1; p-value = 0.016; OR 1.735; CI 95 percent 1.127-2.673). The differences in the frequencies of the O phenotype in patients and controls were statistically different for men (χ2 8.520; DF 1; p-value = 0.003) but not for women (χ2 0.6375; DF 1; p-value = 0.4246). The A phenotype was associated with protection (OR 0.4385; CI 95 percent 0.2043-0.9415; p-value = 0.049) and the O phenotype was associated with susceptibility (OR = 2.789; CI 95 percent 1.385-5.616; p-value = 0.005) to allergic rhinitis only for men.

CONCLUSION:

The O blood group phenotype is associated with allergic rhinitis in male but not in female patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Hipersensibilidade Respiratória / Asma / Sistema ABO de Grupos Sanguíneos / Rinite Alérgica Sazonal / Hipersensibilidade Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Rev. bras. hematol. hemoter Assunto da revista: HEMATOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Hipersensibilidade Respiratória / Asma / Sistema ABO de Grupos Sanguíneos / Rinite Alérgica Sazonal / Hipersensibilidade Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Rev. bras. hematol. hemoter Assunto da revista: HEMATOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil