Results of high-risk neutropenia therapy of hematology-oncology patients in a university hospital in Uruguay
Rev. bras. hematol. hemoter
; Rev. bras. hematol. hemoter;37(1): 28-33, Jan-Feb/2015. tab, graf
Article
em En
| LILACS
| ID: lil-741869
Biblioteca responsável:
BR408.1
Localização: BR408.1
ABSTRACT
Background:
Febrile neutropenia is an important cause of mortality and morbidity in hematology-oncology patients undergoing chemotherapy. The management of febrile neutropenia is typically algorithm-driven. The aim of this study was to assess the results of a standardized protocol for the treatment of febrile neutropenia.Methods:
A retrospective cohort study (2011-2012) was conducted of patients with high-risk neutropenia in a hematology-oncology service.Results:
Forty-four episodes of 17 patients with a median age of 48 years (range 18-78 years) were included. The incidence of febrile neutropenia was 61.4%. The presence of febrile neutropenia was associated with both the duration and severity of neutropenia. Microbiological agents were isolated from different sources in 59.3% of the episodes with bacteremia iso- lated from blood being the most prevalent (81.3%). Multiple drug-resistant gram-negative bacilli were isolated in 62.5% of all microbiologically documented infections. Treatment of 63% of the episodes in which the initial treatment was piperacillin/tazobactam needed to be escalated to meropenem. The mortality rate due to febrile neutropenia episodes was 18.5%.Conclusion:
The high rate of gram-negative bacilli resistant to piperacillin/tazobactam (frontline antibiotics in our protocol) and the early need to escalate to carbapenems raises the question as to whether it is necessary to change the current protocol. .Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Resistência a Medicamentos
/
Protocolos Clínicos
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Infecções por Bactérias Gram-Negativas
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Farmacorresistência Bacteriana
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Doenças Hematológicas
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Neutropenia
Tipo de estudo:
Etiology_studies
/
Guideline
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Uruguay
Idioma:
En
Revista:
Rev. bras. hematol. hemoter
/
Rev. bras. hematol. hemoter. (Online)
/
Revista brasileira de hematologia e hemoterapia (Impresso)
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Uruguai