Apolipoprotein E genotype has no effect on the free intracellular Ca2+ concentration of platelets from Alzheimer's disease patients.
Int J Mol Med
; 3(4): 431-4, 1999 Apr.
Article
em En
| MEDLINE
| ID: mdl-10085419
ABSTRACT
The free intracellular Ca2+ concentration [Ca2+]i of platelets was investigated in Alzheimer's disease (AD) patients and age-matched control subjects with distinct Apo E genotypes. No significant differences were found between the Apo E genotype and the [Ca2+]i levels of platelets (basal and alpha-thrombin stimulated) from AD patients and age-matched control subjects, suggesting that [Ca2+]i homeostasis of platelets from AD patients is independent of the Apo E genotype. The results are discussed in terms of involvement of Apo E and [Ca2+]i changes in the etiopathogenesis of AD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
/
Plaquetas
/
Cálcio
/
Doença de Alzheimer
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Mol Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Portugal