The bioavailability of quinine.

ABSTRACT

Plain tablets of quinine dihydrochloride, quinine bisulphate and quinine sulphate was prepared using salts of similar particle size. Proprietary sugar-coated tablets showed protracted disintegration and dissolution using dialysis method with forced convection and sink conditions was as anticipated by the solubilities. In vivo availability studies indicated release from the plain tablets in the order dihydrochloride, bisulphate, sulphate. The sugar-coated tablets showed delayed release and corresponding low availability: