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Thymus volume correlates with the progression of vertical HIV infection.
Vigano', A; Vella, S; Principi, N; Bricalli, D; Sala, N; Salvaggio, A; Saresella, M; Vanzulli, A; Clerici, M.
Afiliação
  • Vigano' A; Cattedra di Pediatria IV, Università di Milano, Ospedale Luigi Sacco, Milan, Italy.
AIDS ; 13(5): F29-34, 1999 Apr 01.
Article em En | MEDLINE | ID: mdl-10203377
BACKGROUND: The thymus is the organ responsible for the maturation and selection of T lymphocytes and is thus pivotal in allowing the development of a functional immune system. Because in HIV infection cell-mediated immune responses are severely impaired, we studied the role of thymus in the control of the progression of HIV infection to AIDS. METHODS: Thymic volume was analysed by magnetic resonance imaging in 31 vertically HIV-infected children. Plasma HIV viral load and phenotypic and functional cellular immunity-defining parameters were examined in the same patients. RESULTS: Thymic volume was not correlated with age or nutritional status; thymic volume was nevertheless correlated with CD4 T-lymphocyte counts and with the percentage and absolute number of CD45RA+CD62L+ (naive) T lymphocytes. In addition, the ability of peripheral blood mononuclear cells to proliferate upon tetanus stimulation was directly proportional to thymic volume. Finally, a negative correlation was detected between thymic volume and HIV viral load. CONCLUSION: Because low HIV plasma viraemia and preserved immune function are favourable prognostic indices in HIV disease, these data indicate that an immunological, thymic-dependent control of the progression of HIV infection might be possible, at least in vertically transmitted HIV infection.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timo / Infecções por HIV Tipo de estudo: Diagnostic_studies Limite: Child / Humans Idioma: En Revista: AIDS Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Itália
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timo / Infecções por HIV Tipo de estudo: Diagnostic_studies Limite: Child / Humans Idioma: En Revista: AIDS Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Itália