Acute coagulopathy following infusion of prothrombin complex concentrate.
Am J Med
; 60(5): 719-22, 1976 May 10.
Article
em En
| MEDLINE
| ID: mdl-1020759
ABSTRACT
An acute coagulopathy developed in a 49 year old woman with severe liver disease after she received an infusion of prothrombin complex concentrate. The concentrate used in the infusion was subsequently studied by observing the effect of the concentrate on the partial thromboplastin times of various plasmas. The evidence suggests that activated coagulation factors, including activated factor X, were present in the concentrate, and probably played a role in initiating the acute change in the patient's coagulation status. Mechanisms whereby liver disease predisposes toward the development of such a coagulopathy are discussed. It would appear that prothrombin complex concentrates should be used in patients with liver disease only with utmost caution.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator X
/
Protrombina
/
Coagulação Intravascular Disseminada
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Am J Med
Ano de publicação:
1976
Tipo de documento:
Article