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Vascular properties of isoflurane: comparison between normal and cirrhotic rats.
Kirstetter, P; Lagneau, F; Le Corre, F; Cailmail, S; Moreau, R; Lebrec, D; Marty, J.
Afiliação
  • Kirstetter P; Department of Anaesthesia, Hôpital Beaujon, Clichy, France.
Br J Anaesth ; 81(6): 968-9, 1998 Dec.
Article em En | MEDLINE | ID: mdl-10211029
Isoflurane is known to dilate blood vessels and to modulate nitric oxide production. Because cirrhosis is characterized by over production of endothelial nitric oxide, isoflurane-induced vasodilatation may be altered in this situation. We have compared the vasodilator effects of isoflurane in normal rats and rats with secondary biliary cirrhosis. Aortic rings (intact or endothelium denuded) from normal and cirrhotic rats were suspended in HEPES solution and preconstricted with KCl 40 mmol litre-1. Isoflurane dose-dependently relaxed vessels in both groups. Maximal relaxation was comparable between normal and cirrhotic rats in intact (mean 80 (SEM 4) vs 81 (6)%; ns) and in denuded (100 (4) vs 95 (5)%; ns) vessels. Intact vessels relaxed more than denuded vessels in both groups (100 (4) vs 80 (4)% (P = 0.0008) in normal rats and 95 (5) vs 80 (6)% (P = 0.0008) in cirrhotic rats). We conclude that cirrhosis did not modify isoflurane-induced vasodilatation and that the modulator effect of endothelium was conserved.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasodilatação / Anestésicos Inalatórios / Isoflurano / Cirrose Hepática Experimental Limite: Animals Idioma: En Revista: Br J Anaesth Ano de publicação: 1998 Tipo de documento: Article País de afiliação: França
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasodilatação / Anestésicos Inalatórios / Isoflurano / Cirrose Hepática Experimental Limite: Animals Idioma: En Revista: Br J Anaesth Ano de publicação: 1998 Tipo de documento: Article País de afiliação: França