Anonymous oocyte donation performed exclusively with embryos cryopreserved at the pronuclear stage.
Fertil Steril
; 71(5): 830-5, 1999 May.
Article
em En
| MEDLINE
| ID: mdl-10231041
ABSTRACT
OBJECTIVE:
To evaluate the clinical outcomes of patients who participated in an anonymous oocyte donation program that used embryos cryopreserved at the pronuclear stage.DESIGN:
Observational study.SETTING:
A tertiary care reproductive medicine unit. PATIENT(S) Anonymous oocyte donors and their respective recipients. INTERVENTION(S) Oocyte donors underwent a standard controlled ovarian hyperstimulation protocol and transvaginal ultrasound-guided oocyte retrieval. Oocyte recipients underwent at least one programmed hormone replacement cycle with transcervical ET. MAIN OUTCOME MEASURE(S) Thaw survival, implantation, clinical and ongoing pregnancy rates. RESULT(S) Thirty-six oocyte retrievals resulted in one ET to date. The mean numbers of oocytes that were retrieved and normally fertilized were 18.2 and 11.6, respectively. Fifty-one embryo thaw-transfer cycles were performed, with an embryo thaw survival rate of 93.5%. The clinical and ongoing pregnancy rates per ET were 52.9% and 51%, respectively. The overall implantation rate was 28.7%. The percentage of oocyte retrievals that resulted in at least one ongoing pregnancy to date was 69.4%. CONCLUSION(S) Anonymous oocyte donation can be conducted efficiently with the exclusive use of embryos cryopreserved at the pronuclear stage. This approach facilitates synchronization of the donor-recipient pair, eliminates the risk that recipients will begin hormonal therapy without embryo availability, and produces an acceptable ongoing pregnancy rate per oocyte donation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Criopreservação
/
Fase de Clivagem do Zigoto
/
Doação de Oócitos
/
Taxa de Gravidez
/
Desenvolvimento Embrionário e Fetal
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos