Urocanic acid isomers are good hydroxyl radical scavengers: a comparative study with structural analogues and with uric acid.
Biochim Biophys Acta
; 1428(1): 117-20, 1999 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-10366766
ABSTRACT
UV-exposure of the epidermis leads to the isomerisation of trans-UCA into cis-UCA as well as to the generation of hydroxyl radicals. This study shows by means of the deoxyribose degradation test that UCA isomers are more powerful hydroxyl radical scavengers than the other 4-(5-)substituted imidazole derivatives, such as histidine, though less powerful than uric acid. UCA, present in relatively high concentrations in the epidermis, may well be a major natural hydroxyl radical scavenger.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Ácido Úrico
/
Ácido Urocânico
/
Sequestradores de Radicais Livres
/
Radical Hidroxila
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Holanda