Protective effect of the yeast glucomannan against cyclophosphamide-induced mutagenicity.
Mutat Res
; 444(1): 117-22, 1999 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-10477345
ABSTRACT
Glucomannan (GM) isolated from Candida utilis with molecular weight 30 kDa was administered either intraperitoneally or orally prior to cyclophosphamide (CP) injection and its effect on the frequency of micronuclei was evaluated in polychromatic erythrocytes of mouse bone marrow. GM administration by either route decreased significantly (p<0.002) the clastogenic effect of CP. The protective effect was concentration-dependent, with a higher decrease achieved by 200 mg/kg than by 100 mg/kg b. wt. (body weight). The fact that GM was effective also at oral administration is indicative of the passage of GM molecules through the wall of the gastrointestinal tract. The important characteristics of GM isolated from C. utilis, such as good water solubility, relatively small molecular weight (30 kDa), and antimutagenic effect exerted also at oral administration, appear to be promising features for its prospective use as a natural protective agent.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antimutagênicos
/
Ciclofosfamida
/
Mananas
/
Mutagênicos
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1999
Tipo de documento:
Article