Immune responses to antigens of human endogenous retroviruses in patients with acute or stable multiple sclerosis.
J Neuroimmunol
; 99(2): 173-82, 1999 Oct 29.
Article
em En
| MEDLINE
| ID: mdl-10505972
ABSTRACT
A possible role for human endogenous retroviruses (HERV) in the pathogenesis of MS was investigated by analyzing HERV peptides-stimulated proliferation and cytokine production in MS patients with acute (AMS) or stable (SMS) disease. HERV peptides specific-proliferation and type 1 cytokine production by peripheral blood mononuclear cells was observed in AMS but not in SMS individuals, in whom a type 2 cytokine profile dominates. HERV peptides-stimulated immune responses were modified by changes in disease expression; mediated by CD4+ T lymphocytes; and not related to HLA class II molecules. These data suggest the possibility of a pathogenic role for HERV and HERV-specific immune responses in MS.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retrovirus Endógenos
/
Esclerose Múltipla
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Itália