Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21).
Leuk Res
; 23(10): 895-9, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10573134
ABSTRACT
Inactivation of the non translocated TEL/ETV6 gene is commonly associated with translocation (12;21) of acute lymphoblastic leukemia (ALL). Translocations involving the short arm of chromosome 12 were analysed in two children with t(12;21) ALL. Fluorescence in situ hybridation studies showed that these associated translocations resulted in loss of TEL/ETV6. While hybridization with a YAC probe covering TEL/ETV6 was positive in one patient, analysis with cosmid probes covering the gene demonstrated that the gene was in fact deleted. It is concluded that deletions involving TEL/ETV6 can remain undetected by FISH using only YAC probes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Fatores de Transcrição
/
Translocação Genética
/
Cromossomos Humanos Par 12
/
Cromossomos Humanos Par 21
/
Proteínas de Ligação a DNA
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Limite:
Adolescent
/
Child, preschool
/
Female
/
Humans
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
França