Natural infection of chimpanzees with new lentiviruses related to HIV-1/SIVcpz.
J Med Primatol
; 28(4-5): 169-73, 1999.
Article
em En
| MEDLINE
| ID: mdl-10593482
ABSTRACT
To determine newly identified lentiviruses, termed simian immunodeficiency virus (SIV)cpz97CG4 and SIVcpz97CG6, from two wild-captured juvenile brother chimpanzees in the Republic of Congo, subgenomic pol (integrase, 288 bp), 5'tat/rev-env Cl (including vpu, 354 bp) and env (C2-C4, 544 bp) gene fragments were amplified and sequenced. The analysis revealed significantly discordant phylogenetic positions of SIVcpz97CG in each genomic region. In the trees derived from partial env sequences (V3), both SIVcpz strains clustered in human immunodeficiency virus type 1 (HIV-1) subtype A. However, in the trees derived from partial pol (integrase) and 5'tat/rev-env C1 (including vpu) sequences, they clustered independently from any of the known HIV-1 subtypes. Especially, in the 5'tat/rev-vpu tree, they branched before the root of HIV-1 group M. These findings suggest that these Congolese SIVcpz genomes are mosaic, probably due to a recombinational event in the recent past, and it provides evidence for a rather recently occurring cross-species transmission between humans and chimpanzees.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zoonoses
/
Pan troglodytes
/
Vírus da Imunodeficiência Símia
/
Análise de Sequência
/
Lentivirus
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Med Primatol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Japão