Signaling inputs converge on nuclear effectors in TGF-beta signaling.
Trends Biochem Sci
; 25(2): 64-70, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10664585
ABSTRACT
Recent studies have consolidated the pivotal role of Smads as intracellular effectors of TGF-beta family members. Upon binding to their specific type I and type II serine/threonine kinase receptors, each family member activates a particular subset of Smad proteins. Activated, receptor-regulated Smads form hetero-oligomeric complexes with common-partner Smads that translocate into the nucleus, where they control the expression of target genes in a cell-type-specific manner. Smads appear to function not only as nuclear effectors for TGF-beta family members, but as signal integrators within an extensive intracellular network.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Fatores de Transcrição
/
Transdução de Sinais
/
Transativadores
/
Fator de Crescimento Transformador beta
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Suécia