Assessment of regional cerebral blood flow by xenon-enhanced computed tomography during mastication in humans.
Keio J Med
; 49 Suppl 1: A125-8, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10750361
It is suggested that mastication stimulates the brain and accelerates its energy-consuming metabolism. This study was designed to determine its effects on regional cerebral blood flow (rCBF) using xenon-enhanced computed tomography (Xe-CT). Seven male volunteers, aged 24-57 years, inhaled 30% xenon in a 4 minutes wash-in and 4 minutes wash-out protocol. CT was scanned every 54.5 seconds. The subjects were instructed to chew a gum continuously at a rate of 1 bite per second except at the time of CT scanning (5.5 seconds). A second CBF was done 20 minutes later. Subtraction (mastication-baseline) maps were created. CT images were taken at three levels so as to include the cortex, basal ganglia, limbic system, brainstem and cerebellum. The results demonstrated a significant rCBF increase in the fronto-temporal cortex, caudate nucleus, thalamus and minor increase in the rolandic areas, insula, cingulate and cerebellum. Further studies are needed to validate the clinical significance of these findings.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Circulação Cerebrovascular
/
Mastigação
Tipo de estudo:
Guideline
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Keio J Med
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
França