Upregulation of bradykinin B1-receptor expression after myocardial infarction.
Br J Pharmacol
; 129(8): 1537-8, 2000 Apr.
Article
em En
| MEDLINE
| ID: mdl-10780955
ABSTRACT
To determine the influence of the myocardial infarction (MI) on bradykinin B1-receptor (B1R) regulation, we studied its expression in the left ventricle (LV) after MI. Rats were submitted to a permanent occlusion of the left coronary artery. Six hours, 24 h and 6 days after MI or after sham operation, left ventricular pressure (LVP) and dP/dt(max) were measured. LV-total RNA was extracted and B1R expression was analysed by a RNase-protection assay (each group n = 6). LVP and dP/dt(max) were impaired at all time points after MI. Basal B1R expression was not detectable in controls. Six hours after MI, the B1R expression was upregulated and reached a maximum 24 h after MI (4 fold vs. 6 h). Six days post-MI, B1R expression returned to levels found 6 h after MI. These data are the first demonstration for an induced myocardial B1R expression in an in vivo model of MI.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores da Bradicinina
/
Infarto do Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Alemanha