Serum valproate levels in 6 breastfeeding mother-infant pairs.
J Clin Psychiatry
; 61(3): 170-2, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-10817100
ABSTRACT
BACKGROUND:
Women with bipolar disorder are at high risk for recurrence of an affective episode in the postpartum period, and treatment with a mood stabilizer may be indicated. Few data are available to inform the risk-benefit decision regarding the use of valproate for women with bipolar disorder who elect to breast-feed.METHOD:
Serum valproate levels were obtained from 6 breastfeeding mother-infant pairs. All mothers had a diagnosis of bipolar disorder (Research Diagnostic Criteria) and were taking divalproex sodium as prophylaxis for or treatment of a recurrent affective episode. None of the mothers received valproate during pregnancy.RESULTS:
The mothers had serum valproate levels near or within the therapeutic range (39.4 to 79.0 microg/mL). Infant serum levels were low, ranging from 0.7 to 1.5 microg/mL (0.9%-2.3% of maternal serum levels). No adverse clinical effects were observed in the infants.CONCLUSION:
Serum valproate levels were low in nurslings of mothers treated with valproate. These data can be used to inform clinical decisions regarding the use of valproate during breastfeeding.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Puerperais
/
Transtorno Bipolar
/
Aleitamento Materno
/
Ácido Valproico
/
Período Pós-Parto
/
Lactente
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
J Clin Psychiatry
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos