Carbohydrate deficiency of the factor VIII/von Willebrand factor Protein in von Willebrand's disease variants.
Science
; 192(4234): 56-9, 1976 Apr 02.
Article
em En
| MEDLINE
| ID: mdl-1083071
ABSTRACT
Study of the normal human factor VIII/von Willebrand factor reveals a macromolecular glycoprotein composed of apparently identical subunits. This purified glycoprotein has procoagulant, antigen, and von Willebrand factor activities. In three patients with a variant of the von Willebrand's disease syndrome, their factor VIII/von Willebrand factor protein was present in normal amounts and had normal procoagulant and antigen activities; however, this protein was deficient in both carbohydrate and von Willebrand factor activity. The carbohydrate portion of the factor VIII/von Willebrand factor glycoprotein is of major importance in its interactions with platelets or the blood vessel wall, or both.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças de von Willebrand
/
Fatores de Coagulação Sanguínea
/
Fator de von Willebrand
Idioma:
En
Revista:
Science
Ano de publicação:
1976
Tipo de documento:
Article