Shock-induced hyperalgesia: III. Role of the bed nucleus of the stria terminalis and amygdaloid nuclei.
Behav Neurosci
; 114(3): 561-73, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10883806
ABSTRACT
Rats exposed to a few moderately intense (1 mA) shocks subsequently exhibit lower vocalization thresholds to shock and thermal stimuli. They also exhibit facilitated learning in a Pavlovian conditioning paradigm. Together, these results suggest that shock exposure can enhance pain (hyperalgesia). The present study examined the role of the amygdala and bed nucleus of the stria terminalis (BNST), 2 systems that have been implicated in the induction and maintenance of negative affective states. Experiment 1 showed that lesions of the central, but not the basolateral, amygdala eliminate shock-induced hyperalgesia as measured by a decrease in vocalization thresholds to shock. Experiment 2 revealed that central nucleus lesions also prevent shock-induced sensitization of the vocalization response to heat. Anterior, but not posterior, BNST lesions had a similar effect.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleos Septais
/
Limiar da Dor
/
Tonsila do Cerebelo
/
Hiperalgesia
Limite:
Animals
Idioma:
En
Revista:
Behav Neurosci
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos