Age-related qualitative differences in auditory cortical responses during short-term memory.
Clin Neurophysiol
; 111(12): 2234-44, 2000 Dec.
Article
em En
| MEDLINE
| ID: mdl-11090777
ABSTRACT
OBJECTIVE:
To examine the affects of aging on auditory cortical activity during a short-term memory task.METHODS:
Young and elderly subjects performed a working memory task using acoustically presented digits while evoked potential components (N100, P200) generated by auditory cortex were recorded. Reaction time and N100/P200 amplitudes and latency were analyzed as a function of memory load.RESULTS:
N100 amplitude to probes decreased as a function of memory load in young subjects, but increased as a function of memory load in the elderly. Young subjects also exhibited changes in N100 latency during memorization of list items, a result not found in elderly subjects.CONCLUSIONS:
We conclude that normal aging is associated with a qualitatively different pattern of N100 responses during memory retrieval, and a static N100 response during encoding. The findings suggest that aging is accompanied by functional reorganization of the neural network that supports retrieval in auditory working memory.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Auditivo
/
Distribuição por Idade
/
Memória de Curto Prazo
Tipo de estudo:
Qualitative_research
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Neurophysiol
Assunto da revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos