Binding of the La autoantigen to the hepatitis C virus 3' untranslated region protects the RNA from rapid degradation in vitro.
J Gen Virol
; 82(Pt 1): 113-120, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11125164
ABSTRACT
We have analysed hepatitis C virus (HCV) RNAs in an in vitro RNA degradation assay. We found that the 3' end of positive polarity HCV RNA is sensitive to cytosolic RNases whereas the 3' end of negative polarity HCV RNA is relatively stable. Interaction of the HCV 3' untranslated region with the cellular La protein prevented premature degradation of the HCV RNA. One may speculate that HCV RNAs interact with La protein in infected cells to prevent premature degradation of the viral RNAs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribonucleoproteínas
/
Autoantígenos
/
RNA Viral
/
Hepacivirus
/
Regiões 3' não Traduzidas
Limite:
Humans
Idioma:
En
Revista:
J Gen Virol
Ano de publicação:
2001
Tipo de documento:
Article