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Magnetic resonance spectroscopy and histopathological findings in temporal lobe epilepsy.
Stefan, H; Feichtinger, M; Pauli, E; Schäfer, I; Eberhardt, K W; Kasper, B S; Hopp, P; Buchfelder, M; Huk, J; Paulus, W.
Afiliação
  • Stefan H; Department of Neurology, University Erlangen-Nürnberg, Schwabachanlange 6, 90154 Erlangen, Germany. hermann.stefan@neuro.med.uni-erlangen.de
Epilepsia ; 42(1): 41-6, 2001 Jan.
Article em En | MEDLINE | ID: mdl-11207783
ABSTRACT

PURPOSE:

In some patients with temporal lobe epilepsy, histopathological evaluation of resected brain tissue after surgical treatment may reveal several features indicative of discrete cortical malformations. We sought to determine whether these histopathological features were accompanied by hippocampal changes detectable preoperatively by proton magnetic resonance (MR) spectroscopy and to evaluate their relationship with postoperative outcome.

METHODS:

In 25 consecutive temporal lobe epilepsy patients who were scheduled for surgical treatment, MR spectroscopy was performed, and resected brain tissue was analyzed histopathologically for the presence of discrete cortical malformations (e.g., microdysgenesis). Outcome was assessed in all patients with an average postoperative period of 26 months.

RESULTS:

In 13 patients, we found subtle, histopathologically detectable signs of cortical malformation 6 of them with concomitant hippocampal sclerosis (dual pathology) and 7 without. The latter subgroup had a worse surgical outcome and showed enhanced bilateral and/or contralateral pathological changes in the hippocampal formation when investigated by MR spectroscopy.

CONCLUSIONS:

These data suggest that by showing contralaterally or bilaterally abnormal spectra, MR spectroscopy might be able to indicate pathological changes in subtle developmental disorders that are possibly more widespread over the brain. This observation may improve noninvasive diagnosis in presurgical evaluation and the neurobiological understanding of cortical malformations in pharmacoresistant temporal lobe epilepsy.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Temporal / Espectroscopia de Ressonância Magnética / Epilepsia do Lobo Temporal Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Epilepsia Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Alemanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lobo Temporal / Espectroscopia de Ressonância Magnética / Epilepsia do Lobo Temporal Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Epilepsia Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Alemanha