Anergy and human immunodeficiency virus infection.
Med Hypotheses
; 56(3): 376-80, 2001 Mar.
Article
em En
| MEDLINE
| ID: mdl-11359364
ABSTRACT
Human immunodeficiency virus (HIV), the retrovirus associated with acquired immune deficiency syndrome (AIDS), induces a spectrum of immune abnormalities including a state of anergy in the host. This state is due to the binding of HIV envelope glycoprotein moieties to CD4 molecules and chemokine receptors. Resulting decrease in antigen presenting cell function and the interference with functioning of positive and negative regulatory molecules involved in signal transduction have an anergizing effect on the immune system. This effect is exemplified by diminished production of interleukin-2 (IL-2) and interferon-gamma and reduced expression of IL-2 receptor by CD4 helper cells of HIV patients. These immune abnormalities lead to clinically relevant immunological phenomena such as Type-1 to Type-2 switch, decrease in delayed-type hypersensitivity dermal reaction, etc. Insight into these interesting phenomena could pave the path for favorably altering the immunological milieu for drug and vaccine trials.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Anergia Clonal
/
Modelos Imunológicos
Limite:
Humans
Idioma:
En
Revista:
Med Hypotheses
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Canadá