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Anergy and human immunodeficiency virus infection.
Hegde, H R; Robbins, S M.
Afiliação
  • Hegde HR; Department of Paediatrics, Peter Lougheed Centre, Health Science Centre, 3500-26 Avenue NE, Calgary, Alberta, TIY 6J4, Canada.
Med Hypotheses ; 56(3): 376-80, 2001 Mar.
Article em En | MEDLINE | ID: mdl-11359364
ABSTRACT
Human immunodeficiency virus (HIV), the retrovirus associated with acquired immune deficiency syndrome (AIDS), induces a spectrum of immune abnormalities including a state of anergy in the host. This state is due to the binding of HIV envelope glycoprotein moieties to CD4 molecules and chemokine receptors. Resulting decrease in antigen presenting cell function and the interference with functioning of positive and negative regulatory molecules involved in signal transduction have an anergizing effect on the immune system. This effect is exemplified by diminished production of interleukin-2 (IL-2) and interferon-gamma and reduced expression of IL-2 receptor by CD4 helper cells of HIV patients. These immune abnormalities lead to clinically relevant immunological phenomena such as Type-1 to Type-2 switch, decrease in delayed-type hypersensitivity dermal reaction, etc. Insight into these interesting phenomena could pave the path for favorably altering the immunological milieu for drug and vaccine trials.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Anergia Clonal / Modelos Imunológicos Limite: Humans Idioma: En Revista: Med Hypotheses Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Canadá
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Anergia Clonal / Modelos Imunológicos Limite: Humans Idioma: En Revista: Med Hypotheses Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Canadá