Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Blood
; 98(2): 428-35, 2001 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-11435313
ABSTRACT
Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon MM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)-independent Raf-1-MEK-extracellular signal-regulated protein kinase pathway, and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Divisão Celular
/
Movimento Celular
/
Fatores de Crescimento Endotelial
/
Linfocinas
/
Mieloma Múltiplo
Limite:
Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos