Effects of MCI-154, a calcium sensitizer, on cardiac function in endotoxemic rabbits.
Acta Pharmacol Sin
; 21(9): 824-9, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-11501165
ABSTRACT
AIM:
To observe the effects of MCI-154, a calcium sensitizer, on cardiac function after endotoxic shock.METHODS:
The rabbits were intravenously injected with MCI-154 0.1 mg.kg-1 at 10 h after the administration of endotoxin 1.0 mg.kg-1, followed by a continuous infusion of normal saline (NS) 50 mL.kg-1 + MCI-154 0.1 mg.kg-1. During this process, the parameters of cardiac function were measured.RESULTS:
Ten hours after the endotoxin injection, heart rate (HR) increased noticeably while the mean arterial blood pressure (MAP), left ventricular systolic pressure (LVSP), isovolumetric pressure (IP), myocardial contractility (MC), and the area of p-dp/dtmax vector loop (Lo) were all markedly decreased. Treatment with NS 50 mL.kg-1 alone had slight effects on these parameters. LVSP, IP, MC, and Lo were all markedly increased while HR did not obviously change and left ventricular end-diastolic pressure (LVEDP) was reduced markedly following MCI-154 administration in endotoxic shock rabbits. The parameters of MC were improved nearly to the same values as in sham shock group and were markedly higher than in NS treated group.CONCLUSION:
MCI-154 exerts remarkable therapeutic effects on cardiac dysfunction after endotoxic shock.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridazinas
/
Choque Séptico
/
Cardiotônicos
/
Função Ventricular Esquerda
Limite:
Animals
Idioma:
En
Revista:
Acta Pharmacol Sin
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
China