Exposure to altered gravity affects all stages of endochondral cartilage differentiation.
Adv Space Res
; 24(6): 821-7, 1999.
Article
em En
| MEDLINE
| ID: mdl-11542628
ABSTRACT
Chondrogenesis has a number of well-defined steps:
(1) condensation, which involves cell aggregation, adhesion and communication; (2) activation of cartilage genes, which is accompanied by rounding up of the cells and intracellular differentiation; and (3) production and secretion of cartilage specific matrix molecules. Our studies show that each of these steps is affected by exposure to gravitational changes. Clinorotation and centrifugation affected initial aggregation and condensation. In the CELLS experiment, where cells were exposed to microgravity after some condensation occurred preflight, intracellular differentiation and matrix production were delayed relative to controls. Once cartilage has developed, in rats, further differentiation (hypertrophy, matrix production) was also affected by spaceflight and hind limb suspension. For the process of chondrogenesis to proceed as we know it, loading and other factors present at 1g are required at each step of the process. This requirement means that not only will skeletal development and bone healing, processes involving chondrogenesis, be altered by long term exposure to microgravity, but that continuous intervention will be necessary to correct any defects produced by altered gravity environments.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Voo Espacial
/
Ausência de Peso
/
Desenvolvimento Ósseo
/
Cartilagem
/
Condrogênese
Limite:
Animals
Idioma:
En
Revista:
Adv Space Res
Assunto da revista:
MEDICINA AEROESPACIAL
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos