Influence of steroids on microvascular perfusion injury of the bowel induced by extracorporeal circulation.
Ann Thorac Surg
; 72(4): 1321-6, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11603454
ABSTRACT
BACKGROUND:
Extracorporeal circulation is associated with gastrointestinal complications. By means of intravital microscopic methods, we investigated whether preoperative treatment with steroids can attenuate the impairment of the bowel microcirculation.METHODS:
In 20 pigs, a partial left heart bypass (pLHB) was established. A loop of the terminal ileum was exteriorized for intravital-microscopic observation. Seven sham-operated animals served as controls. In 13 animals, pLHB was established for 2 hours with a flow rate of 2,000 mL per minute; 7 of the animals received 20 mg/kg body weight prednisolone preoperatively. The microcirculatory network was analyzed before, during pLHB, and 2 hours after bypass.RESULTS:
Despite unchanged macro-hemodynamics, pLHB resulted in a significant microvascular perfusion injury of the small bowel. Arteriolar vasoconstriction and a reduction of perfused capillaries per unit area (functional capillary density) to 30% of prebypass values could be found. Blood cell velocities were reduced in submucuous collecting venules. In the steroid-treated animals, the functional capillary density remained normal. In addition, arteriolar vasoconstriction could be prevented.CONCLUSIONS:
Treatment with prednisolone largely prevents the microcirculatory alterations in the small bowel induced by extracorporeal circulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Medicação
/
Prednisolona
/
Traumatismo por Reperfusão
/
Circulação Extracorpórea
/
Intestinos
Limite:
Animals
Idioma:
En
Revista:
Ann Thorac Surg
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Alemanha