Asymmetric Synthesis of Calyculin C. 1. Synthesis of the C(1)-C(25) Fragment.
J Org Chem
; 61(18): 6139-6152, 1996 Sep 06.
Article
em En
| MEDLINE
| ID: mdl-11667448
ABSTRACT
We report our synthesis of the C(1)-C(25) fragment of serine/threonine phosphatase PP1 and PP2A inhibitor, calyculin C. Synthetic efforts were directed initially toward the synthesis of a spiroketal core fragment (7), which culminated in completion of the bottom half of the natural product. The synthesis of fragment 7 and subsequent elaboration relied on an allylboration strategy for introduction of chirality. The C(1)-C(8) fragment representing the potentially unstable tetraene moiety was introduced as a separate entity.
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01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
1996
Tipo de documento:
Article