Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway.
Neuron
; 32(4): 591-604, 2001 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-11719201
ABSTRACT
The organizing centers and molecules that pattern the cerebral cortex have been elusive. Here we show that cortical patterning involves regulation of the Lhx2 homeobox gene by the roof plate. Roof plate ablation results in reduced cortical size and Lhx2 expression defects that implicate roof plate signals in the bimodal regulation of Lhx2 in vivo. Bimodal Lhx2 regulation can be recapitulated in explants using two roof plate-derived signaling molecules, Bmp4 and Bmp2. Loss of Lhx2 function results in profound losses of cortical progenitors and neurons, but Lhx2 mutants continue to generate cortical neurons from dorsal sources that may include the roof plate region itself. These findings provide evidence for the roof plate as an organizing center of the developing cortex and for a roof plate-Lhx2 pathway in cortical patterning.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Córtex Cerebral
/
Fator de Crescimento Transformador beta
/
Proteínas de Homeodomínio
/
Regulação da Expressão Gênica no Desenvolvimento
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos