Involvement of endometrial membrane sulphydryl groups in blastocyst implantation: sulphydryl groups as a potential target for contraceptive research.
Contraception
; 64(4): 255-9, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11747876
ABSTRACT
The role of membrane sulphydryl groups in blastocyst implantation was studied by masking the membrane sulphydryl groups in the endometrium of Swiss albino mice, Mus musculus, using 10(-5) M cobalt chloride and 0.05 mM as well as 0.005 mM n-ethylmaleimide. Here we show that the blocking of sulphydryl groups with cobalt resulted in a decrease in superoxide radical surge and an increase in superoxide dismutase levels at the time of implantation. We hypothesize that it may be due to either a decrease in membrane fluidity or the unavailability of sulphydryl groups of endometrial membrane, thus preventing blastocyst implantation. These sulphydryl groups can be targeted for future contraceptive research.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
/
Compostos de Sulfidrila
/
Blastocisto
/
Endométrio
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Contraception
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Índia