Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
Science
; 295(5553): 338-42, 2002 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-11786644
ABSTRACT
T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 cytokine, interferon-gamma (IFN-gamma). IFN-gamma is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Linfócitos T Citotóxicos
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Linfócitos T CD4-Positivos
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Interferon gama
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Células Th1
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos