Nef and LTR sequence variation from sequentially derived human immunodeficiency virus type 1 isolates.
Virology
; 208(1): 388-98, 1995 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-11831726
ABSTRACT
Variation in HIV-1 nef and LTR DNA sequences was assessed longitudinally during disease progression in four HIV-1-infected subjects. Point mutations were found among quasispecies obtained at a single time point in each individual, with increasing diversity with disease progression in two of three patients for whom sufficient data were available for analysis. Deletions and rearrangements were more common in late than early stages of disease. Continued sequence evolution in HIV-1 quasispecies with nef deletions along with coexistence of nef-bearing quasispecies suggest that nef-deleted quasispecies are capable of replication in vivo, possibly complemented by quasispecies lacking such deletions and/or by adaptation to a specialized niche within the patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos do Gene nef
/
Infecções por HIV
/
Repetição Terminal Longa de HIV
/
HIV-1
Limite:
Humans
Idioma:
En
Revista:
Virology
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos