Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives.
Bioorg Med Chem Lett
; 12(4): 589-91, 2002 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-11844678
ABSTRACT
General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally active compounds with potent in vitro and in vivo anti-angiogenesis and anti-tumor activities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridazinas
/
Inibidores da Angiogênese
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Bélgica